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Nasal decongestant - How they act?

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nasal decongestants what are them hazard

decongestants these nasal decongestants

contain the drugs such as alpha one

agonies and they produce nasal

vasoconstriction locally so they relieve

the congestion so our phone a goon is

mainly act as the nasal decongestants so

this is one of the drug which is an

alpha one OCONUS and this is phenol a

frame you can compare this finale frame

with the what of the katha calamine

epinephrine so even if he is having this

type of structure what is the difference

between these two if you observe

phenylephrine is having no Oh H group at

the third portion so phenylephrine is

not a catechol MI and it lacks the

voyage group at the third portion so

because of this lack of voyage group now

phenylephrine is selective for the alpha

1 receptors actually a prefering is

selective for both alpha as well as beta

is Aptos

but Finn anything because of lack of

voyage group at the third question it is

said to further alpha 1 receptors so

phenylephrine is a select 2 alpha 1

agonist similar other alpha 1 agonies

include this is the one of the tribe

xylem at azzolini this rug is having the

imagery nucleus this emitted role in

nucleus is attached to the final ring

which is again attached with the two

methyl groups so this finally gives the

xylene ring this is a drug having xylem

ring system which is attached to the

image or in metal side shine so this is

the Xylo meta Zoli and then the drug

here is the oxymetazoline and you can

observe the only difference is

oxymetazoline xanga which group adds

into the methyl group on the bedsheet so

these are the two brags Zeno matazo lean

and oxymetazoline

which are the image rolling derivatives

similarly and the drug is the NAFA

jolene

you can observe that in the Navajo lean

naphthyl ring system is present which is

again attached to the emitter jolene

ring system one of the advantage of this

novel jolene is that this can be used

both for nasal as well as ocular

congestion so it is not only a nasal

decongestant it is also an ocular

decongestant

what are other nasal decongestants so

this is a monofin mix it acting track

which is having the voyage group with

our configuration and methyl group with

s configuration so this is the drug if

it drain which is hang one or two s

configuration similarly its isomer is

the pseudo F it drain which is hanging

the S configuration at the o hitch and

our conversation at the CH T so shrewder

if it really has oneness to our

configuration if we train previously

used as a nasal decongestant and

bronchodilator but nowadays it is not

preferred as a nasal decongestant

because of its adverse effects on the

cardiovascular system as well as its

effect on the drug addiction so pseudo

if it ring is only one of the drug used

as a nasal decongestant

how they act so these nasal

decongestants mainly act on the alpha 1

receptor so let us see how these tags

are mainly acting so suppose this is a

nasal mask class smooth muscle notice

nasal vascular smooth muscle is equipped

with the alpha 1 receptors and whenever

nasal decongestants act as a gonna stir

on this alpha 1 receptors these

receptors are activated so that they

will convert the fast water in - tall to

the fast water to - talk activated

system

now this phosphatidyl Ida star which is

activated then releases the ip3 and

diacylglycerol I know start triphosphate

and diacylglycerol now these two minute

us are espousal for the increase in the

within the vast glass smooth muscle now

the razor calcium within the vascular

smooth muscle leads to the contraction

of the last class smooth muscle in this

way nasal decongestants produce

vasoconstriction at the nasal blood

vessels but how this can produce the

reef of congestion so suppose this is

the normal blood vessel under normal

conditions but when it is under when the

vasodilatation because of the congestion

the nasal blood results are going to be

dilated now when these are dilated the

nasal pathway is going to be congested

so that results in the stuffy nose and

difficulty in breathing in such

situation nasal decongestants can cause

vasoconstriction of the nasal blood

vessels thereby they increased and nasal

pathway leading to the relief of the

condition seen this way nasal

decongestants acts as a local

vasoconstrictors within the nasal blood

vessels so this vasoconstriction of the

nasal that results cause a relief of the

nasal block what are the side effects of

these drugs because these let's act

locally they also produce local side

effects so the first one is the nasal

irritation

sneezing burning and nasal sinus as

these drugs are going to decrease the

nasal secretions

so in hazzard dryness is also observed

with these strikes so all these are the

local effects which can be easily

tolerated

apart from these side effects one of the

limitation of the nasal decongestants is

the rebound condition so the rebound

condition is a one of a reverse effect

of the nasal decongestants when they are

used continuously for more than three

days so in such situation they increase

the condition by increasing the swelling

redness as well as the nasal block so

the exact mechanism for this is not

clear but any contracting mechanisms may

be developer within these three days

which may further increase the

condition how these dads are given so

these drugs are given as nasal sprays so

fear of the lights which are given as an

acid sprays include the drugs like

oxymetazoline Xylo meta saline and

pseudoephedrine similarly these lips can

also be given as the syrups as well as

tablets so throughout the night which

are given as syrups and tablets include

phenylephrine and pseudo fa dream you

can observe that sooner if a drink can

be given as a nasal spray syrups as well

as tablets that's about the nasal

decongestants nasal decongestants or the

drugs which produce a quick and prompt

relief of the nasal condition and have

an important role in the nasal block and

stuffy nose but only one of the

limitation of these drugs is that this

drug should be used one for less than

three days and when they are used for

more than three days they can further

increase the nasal congestion

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